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Lastly, clonidine improves neuraxial opioids and, in combination with fentanyl, interacts in an additive manner, which can reduce the dose of each ingredient by 60% for postoperative analgesia.Jun 10, 2024 · If clonidine therapy will be to be replaced by a β-blocker, delay administration of the β-blocker for a number of days after clonidine the